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刘红荣 教授

作者:时间:2020-06-08 08:36浏览次数:

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个人简介

刘红荣,湖南科技大学物理系本科,湘潭大学凝聚态物理博士,美国加州大学洛杉矶分校博士后,现任湖南师范大学二级教授,博士生导师。刘红荣长期从事电子显微成像相关的理论与实验工作,在冷冻电镜三维重构领域做出了系列原创性成果,在Science、PNAS、Nat Commun、Protein & Cell等期刊发表学术论文40余篇,相关成果被同行评价为“当代电子显微学的代表作”、“里程碑式发现”等;先后获得了教育部“长江学者奖励计划” 特聘教授、国家“万人计划”科技创新领军人才等荣誉。

办公室:量子楼316

Email: hrliu@hunnu.edu.cn,hrliu2013@126.com 

学术贡献

电子显微学及其应用;凝聚态物理中的交叉学科 

教学情况

X射线与电子显微学;光学;计算物理;凝聚态物理前沿 

承担课题

 1. 湖南省自科基金创新群体项目:显微成像理论及生物应用(2019JJ10002).

 2. 湖南省科技领军人才项目(2017RS3033).

 3. 国家重点研发计划课题:冷冻电镜原子分辨结构解析高效算法的开发与应用(2016YFA0501103).

 4. 国家自然科学基金重大研究计划(高性能科学计算的基础算法与可计算建模)集成项目:冷冻电镜三维重构的关键算法研究及其应用(91530321).

 5. 国家自然科学基金面上项目:基于冷冻电镜二十面体对称失配三维重构的腺病毒结构研究(31570742).

 6. 教育部新世纪优秀人才支持计划(NCET-13-0787).

 7. 国家自科基金面上项目:双链RNA病毒甲基转移酶活性位点的空间定位—冷冻电镜原子分辨三维重构(31370736).

 8. 湖南省杰出青年基金:冷冻电镜近原子分辨三维重构的新算法研究(13JJ1017).

 9. 国家自然科学基金重大研究计划培育项目(高性能科学计算的基础算法与可计算建模):基于球坐标系的冷冻电镜二十面体病毒高分辨三维重构的算法研究(91230116).

 10. 教育部科技研究重点项目:对称匹配函数在冷冻电镜单颗粒技术中的应用 (212119).

 11. 国家自科基金面上项目:最大熵方法在冷冻电镜单颗粒技术中的应用(31170706).

 12. 国家自科基金面上项目:冷冻电镜单颗粒技术中测定生物大分子颗粒取向的新算法研究(31070663).

代表性论文

 1.  Shuai Yuan, Jialing Wang, Dongjie Zhu, Nan Wang, Qiang Gao, Wenyuan Chen, Hao Tang, Junzhi Wang*, Xinzheng Zhang*, Hongrong Liu*, Zihe Rao*, and Xiangxi Wang*, Cryo-EM structure of a Herpesvirus capsid at 3.1 Å, Science 2018, 360: eaao7283.

 2.  Hongrong LiuLingpeng Cheng*,Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus, Science 2015349: 1347-1350.

 3.  Hongrong LiuLei JinSok Boon S. KohIvo AtanasovStan ScheinLily WuZ Hong Zhou*. Atomic structure of human adenovirus by cryoEM reveals interactions among protein networks, Science 329(2010): 1038-1043.

 4.  Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, Lingpeng Cheng*. Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly. Proc Natl Acad Sci USA 2018, 115: 7344-7349.

  5.  Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu*, Xinzheng Zhang*, Zihe Rao*, and Xiangxi Wang*. Structure of the herpes simplex virus type 2 Ccapsid with capsid-vertex-specific component. Nat Commun 2018, 9:3668.

  6.  Wenyuan Chen#, Hao Xiao#, Xurong Wang, Shuanglin Song, Zhen Han, Xiaowu Li, Fan Yang,Li Wang, Jingdong Song*, Hongrong Liu*, Lingpeng Cheng*. Structural changes of a bacteriophage upon DNA packaging and maturation, Protein Cell 2020, 11(5):374–379.

  7.  Nan Wang#, Wenyuan Chen#, Ling Zhu#, Dongjie Zhu, Rui Feng, Jialing Wang, Bin Zhu, Xinzheng Zhang, Xiaoqing Chen, Xianjie Liu, Runbin Yan, Dongyao Ni, Grace Guoying Zhou, Hongrong Liu*, Zihe Rao*, Xiangxi Wang*. Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Protein Cell 2020, 11(5):366–373.

  8.  Xiaowu Li, Li Wang, Xurong Wang, Wenyuan Chen, Tao Yang, Jingdong Song*, Hongrong Liu*, LingpengCheng*, Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis, J Mol Biol 2020, 432: 358-366.

  9.  Xiaolong Li, Mingyang Jiang, Songjun Zeng*and Hongrong Liu*, Polydopamine coated multifunctional lanthanide theranostic agent for vascular malformation and tumor vessel imaging beyond 1500 nm and imaging-guided photothermal therapy, Thranostics 2019, 9: 3866-3878.

  10.  Zhiming Deng, Xiaolong Li, Zhenluan Xue, Mingyang Jiang, Youbin Li, Songjun Zeng* and Hongrong Liu*A high performance Sc-based nanoprobe for through-skull fluorescence imaging of brain vessels beyond 1500 nmNanoscale, 2018,10, 9393-9400.

  11.  Bin Zhu, Lingpeng Cheng*, Hongrong Liu*, Computing methods for icosahedral and symmetry-mismatch reconstruction of viruses by cryo-electron microscopy, Chin Phys B 2018, 27(5): 056802.

  12.  Xiaolong Li, Zhengluan Xue, Youbin Li, Songjun Zeng*, and Hongrong Liu*, Soft X-ray activated NaYF4:Gd/Tb scintillating nanorods for in vivo dual-modal X-ray/X-ray-induced optical bioimaging, Nanoscale 2017, 10(1): 342-350.

  13.  Xiaowu Li, Niyun Zhou, Wenyuan Chen, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*, and Lingpeng Cheng*. Near-atomic resolution structure determination of a cypovirus capsid and polymerase complex using cryo-EM at 200 kV, J Mol Biol 2017, 429: 79-87.

  14.  Xiaowu Li, Hongrong Liu*, Lingpeng Cheng*, Symmetry-mismatch reconstruction of genomes and associated proteins within icosahedral viruses using cryo-EM, Biophys Rep 2016, 2: 25-32.

  15.  Bin Zhu, Chongwen Yang, Hongrong Liu*, Lingpeng Cheng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, Ping Zhu, Identification of the Active Sites in the Methyltransferases of a Transcribing dsRNA Virus, J Mol Biol 2014, 426: 2167-2174.

  16.  Changchun Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji, Lingpeng Cheng*, and Hongrong Liu*, Conserved fiber-penton base interaction revealed by a near-atomic resolution cryo-EM structure of adenovirus provides insight into receptor interaction, J Virol 2012, 86: 12322-12329.

  17.  Hongrong LiuLily Wu, Z Hong Zhou*. Model of the trimeric fiber of human adenovirus 5 and its interactions with the pentameric penton base by cryo-electron microscopy, J Mol Biol 2011, 406: 764-774.

  18.  Hongrong Liu, Lingpeng Cheng, Songjun Zeng, Canying Cai Z. Hong Zhou, Qibin Yang*, Symmetry-adapted spherical harmonics method for high-resolution 3D single particle reconstructions, J Strul Boil 2008, 161: 64-73.

获奖情况

 1. 教育部“长江学者奖励计划”特聘教授(2019

 2. 湖南师范大学利君育人先锋奖2018

 3. 第七届中国侨界贡献奖二等奖(2018

 4. 国家万人计划科技创新领军人才(2017

 5. 湖南省科技领军人才(2017

 6. 全省教育系统优秀共产党员(2016

 7. 科技部创新人才推进计划中青年科技创新领军人才(2017

 8. 国务院政府特殊津贴专家(2016

 9. 湖南省优秀科技工作者(2016

 10. 教育部新世纪优秀人才(2013

 11. 湖南省杰出青年基金获得者(2012

 

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